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Bcl2相關(guan) 抗凋亡基因6抗體(ti)
產(chan) 品名稱 | 英文名稱 | 貨號 |
Bcl2相關(guan) 抗凋亡基因6抗體(ti) | BAG6 | GOY-01K1620 |
商品屬性：
英文名稱: BAG6
中文名:Bcl2相關(guan) 抗凋亡基因6抗體(ti)
別 名；family molecular chaperone regulator 6; BAG-6; BAG6; Bag6;
BAG6_HUMAN; BCL2-associated athanogene 6; D6S52E; G3; HLA B associated
transcript 3; HLA-B-associated transcript 3; Large proline-rich protein BAG6;
Protein G3; Protein Scythe.
研究領域；腫瘤 細胞生物 細胞凋亡
抗體(ti) 來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chan) 品應用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修複）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量；119kDa
細胞定位；細胞核 細胞漿 細胞外基質
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human BAT3/BAG6: 1042-1132/1132
亞(ya) 型；IgG
純化方法；affinity
purified by Protein A
緩 衝(chong) 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chan) 品介紹:
Chaperone that plays a key role in various
processes such as apoptosis, insertion of tail-anchored (TA) membrane
proteins to the endoplasmic reticulum membrane and regulation of chromatin.
Acts in part by regulating stability of proteins and their degradation by the
proteasome. Participates in endoplasmic reticulum stress-induced apoptosis
via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and
preventing its degradation. Also required during spermatogenesis for synaptonemal
complex assembly via its interaction with HSPA2, by inhibiting
polyubiquitination and subsequent proteasomal degradation of HSPA2. Required
for selective ubiquitin-mediated degradation of defective nascent chain
polypeptides by the proteasome. In this context, may play a role in
immuno-proteasomes to generate antigenic peptides via targeted degradation,
thereby playing a role in antigen presentation in immune response. Key
component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved
in the post-translational delivery of tail-anchored (TA) membrane proteins to
the endoplasmic reticulum membrane. TA membrane proteins, also named type II
transmembrane proteins, contain a single C-terminal transmembrane region.
BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40:
it is recruited to ribosomes synthesizing membrane proteins, interacts with
the transmembrane region of newly released TA proteins and transfers them to
ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. Function: Serine-threonine kinase which transduces
inflammatory and cell-death signals (necroptosis) following death receptors
ligation, activation of pathogen recognition receptors (PRRs), and DNA
damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and
TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via
'Lys-63'-link chains acts as a critical enhancer of communication with
downstream signal transducers in the mitogen-activated protein kinase pathway
and the NF-kappa-B pathway, which in turn mediate downstream events including
the activation of genes encoding inflammatory molecules. Polyubiquitinated
protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a
critical event for NF-kappa-B activation. Interaction with other cellular
RHIM-containing adapters initiates gene activation and cell death. RIPK1 and
RIPK3 association, in particular, forms a necroptosis-inducing complex. |
多克隆抗體(ti) 製備：
我公司合成抗原，保證陽性血清和抗體(ti) ELISA效價(jia) 達到1：32000，由蛋白抗原製備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價(jia) ，按節點收費，為(wei) 客戶節約成本。
鼠單克隆抗體(ti) 製備:
客戶可根據項目實際需求情況靈活選擇進行，我公司將為(wei) 您的項目提供專(zhuan) 業(ye) 的建議。在製備過程中，與(yu) 客戶互動驗證，確保最終製備的抗體(ti) ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體(ti) 最終應用驗證需求。技術服務實行分步報價(jia) ，按節點收費，為(wei) 客戶節約成本。
重組抗體(ti) 表達服務:
重組抗體(ti) 技術使製備人源化抗體(ti) 和人源抗體(ti) 成為(wei) 可能，而這是其他常規的多克隆或單克隆抗體(ti) 製備方法無法做到的。我公司已搭建好的抗體(ti) 測序、重組抗體(ti) 表達等先進平台，能為(wei) 客戶提供各種類型的重組抗體(ti) 表達服務，包含鼠源單克隆抗體(ti) 構建及表達、更換恒定區亞(ya) 型的嵌合抗體(ti) 表達，抗體(ti) 人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為(wei) 客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yang) 、抗體(ti) 修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體(ti) 定製服務:
已注冊(ce) 商標，主要用於(yu) 抗體(ti) 藥物發現和開發，是我公司針對有特定應用要求和各種模型測試的客戶量身定製的專(zhuan) 業(ye) 服務，主要麵向工業(ye) 客戶。
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