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α2巨球蛋白樣蛋白1抗體(ti) α2ML1
產(chan) 品名稱 | 英文名稱 | 貨號 |
α2巨球蛋白樣蛋白1抗體(ti) α2ML1 | A2ML1 | GOY-01K1267 |
商品屬性：
英文名稱: A2ML1
中文名:α2巨球蛋白樣蛋白1抗體(ti) α2ML1
別 名；A2ML 1; Alpha 2
macroglobulin like 1; Alpha 2 macroglobulin like protein 1; C3 and PZP like
alpha 2 macroglobulin domain containing protein 9; CPAMD9; DKFZp686C1729;
DKFZp686D2011; DKFZp686G1812; DKFZp686L1821; DKFZp686O1010; FLJ16045; FLJ25179;
FLJ39129; FLJ41597; FLJ41598; FLJ41607; A2ML1_HUMAN. α2ML1
研究領域；細胞生物 免疫學 神經生物學
抗體(ti) 來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Horse, )
產(chan) 品應用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；159kDa
細胞定位；細胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human A2ML1: 31-130/1454
亞(ya) 型；IgG
純化方法；affinity
purified by Protein A
緩 衝(chong) 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chan) 品介紹:
alpha-2-Macroglobulin (alpha-2M) is a
homotetrameric serum protein consisting of four identical subunits that form
dimers through disulfide bonds. Initially, alpha-2M was characterized as a
pan-proteinase inhibitor that was able to “bait” proteinases into cleaving specific
peptide sequences on alpha-2M. This interaction induces a conformational
change in alpha-2M, thus enabling it to “trap” the proteinase and further inhibit its activity. Subsequently,
alpha-2M has been shown to function as a carrier protein and regulator of
cytokines during inflammation. Circulating transforming growth factor beta
(TGF beta) in serum is primarily bound to alpha-2M, which renders TGF∫ inactive. Mutations and deletions in the gene encoding alpha-2M
are associated with an increased incidence of Alzheimer's Disease (AD).
Alpha-2-macroglobulin-like protein 1 (alpha2ML1) is a related protein that is
expressed in the epidermis and may play a role in keratinocyte
differentiation. A2ML1 is a new member of the alpha 2-macroglobulin
protease inhibitor family, and shares most the characteristics of this
family. It is the first family member detected in the epidermis and may play
an important role during desquamation by inhibiting extracellular proteases.
The alpha-macroglobulin (AM) superfamily of proteins contains both complement
components and protease inhibitors, including A2M and A2ML1. AM proteins
display a unique trap mechanism of inhibition, by which the AM inhibitor
undergoes a major conformational change upon its cleavage by a protease, thus
trapping the protease and blocking it from subsequent substrate binding. |
多克隆抗體(ti) 製備：
我公司合成抗原，保證陽性血清和抗體(ti) ELISA效價(jia) 達到1：32000，由蛋白抗原製備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價(jia) ，按節點收費，為(wei) 客戶節約成本。
鼠單克隆抗體(ti) 製備:
客戶可根據項目實際需求情況靈活選擇進行，我公司將為(wei) 您的項目提供專(zhuan) 業(ye) 的建議。在製備過程中，與(yu) 客戶互動驗證，確保最終製備的抗體(ti) ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體(ti) 最終應用驗證需求。技術服務實行分步報價(jia) ，按節點收費，為(wei) 客戶節約成本。
重組抗體(ti) 表達服務:
重組抗體(ti) 技術使製備人源化抗體(ti) 和人源抗體(ti) 成為(wei) 可能，而這是其他常規的多克隆或單克隆抗體(ti) 製備方法無法做到的。我公司已搭建好的抗體(ti) 測序、重組抗體(ti) 表達等先進平台，能為(wei) 客戶提供各種類型的重組抗體(ti) 表達服務，包含鼠源單克隆抗體(ti) 構建及表達、更換恒定區亞(ya) 型的嵌合抗體(ti) 表達，抗體(ti) 人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為(wei) 客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yang) 、抗體(ti) 修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體(ti) 定製服務:
已注冊(ce) 商標，主要用於(yu) 抗體(ti) 藥物發現和開發，是我公司針對有特定應用要求和各種模型測試的客戶量身定製的專(zhuan) 業(ye) 服務，主要麵向工業(ye) 客戶。
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