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B淋巴細胞基因1抗體(ti)
產(chan) 品名稱 | 英文名稱 | 貨號 |
B淋巴細胞基因1抗體(ti) | TLE4 | GOY-01K2036 |
商品屬性：
英文名稱: TLE4
中文名:B淋巴細胞基因1抗體(ti)
別 名；B lymphocyte gene
1; B lymphocyte gene 1; enhancer of split groucho 4; enhancer of split groucho
4; ESG4; ESG4; KIAA1261; TIM; TIM1; timeless (Drosophila) homolog; TLE4;
transducin-like enhancer of split 4; transducin-like enhancer of split 4;
TLE4_HUMAN.
研究領域；腫瘤 細胞生物 染色質和核信號 神經生物學 信號轉導 幹細胞 轉錄調節因子 細胞分化
抗體(ti) 來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chan) 品應用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修複）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；84kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human TLE4: 681-773/773
亞(ya) 型；IgG
純化方法；affinity
purified by Protein A
緩 衝(chong) 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chan) 品介紹:
The Notch signaling pathway controls cellular
interactions important for the specification of a variety of fates in both
invertebrates and vertebrates. Key players in the Notch pathway are the TLE
genes (for transducin-like enhancer of split, also designated ESG for
enhancer of split groucho), which are human homologs of the Drosophila
groucho gene. Groucho is a transcriptional repressor that plays a key role in
neurogenesis, segmentation and sex determination. TLEs associate with
chromatin in live cells and specifically with Histone H3, but not with other
core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4,
correlate with immature epithelial cells that are progressing toward a
terminally differentiated state, suggesting a role during epithelial
differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical
squamous metaplasias and carcinomas, while TLE4 is most highly expressed in
the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and
WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced
transactivation of the CSF1 receptor. In early stages of cell
differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In
later stages, TLE2 and TLE4 are upregulated, and expression of TLE1
decreases. Function: TLE4 (Transducin-like enhancer protein 4) is a
member of the Groucho family of transcriptional corepressors and inhibits the
transcriptional activation mediated by Pax5 and by beta-catenin and TCF
family members in Wnt signaling. |
多克隆抗體(ti) 製備：
我公司合成抗原，保證陽性血清和抗體(ti) ELISA效價(jia) 達到1：32000，由蛋白抗原製備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價(jia) ，按節點收費，為(wei) 客戶節約成本。
鼠單克隆抗體(ti) 製備:
客戶可根據項目實際需求情況靈活選擇進行，我公司將為(wei) 您的項目提供專(zhuan) 業(ye) 的建議。在製備過程中，與(yu) 客戶互動驗證，確保最終製備的抗體(ti) ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體(ti) 最終應用驗證需求。技術服務實行分步報價(jia) ，按節點收費，為(wei) 客戶節約成本。
重組抗體(ti) 表達服務:
重組抗體(ti) 技術使製備人源化抗體(ti) 和人源抗體(ti) 成為(wei) 可能，而這是其他常規的多克隆或單克隆抗體(ti) 製備方法無法做到的。我公司已搭建好的抗體(ti) 測序、重組抗體(ti) 表達等先進平台，能為(wei) 客戶提供各種類型的重組抗體(ti) 表達服務，包含鼠源單克隆抗體(ti) 構建及表達、更換恒定區亞(ya) 型的嵌合抗體(ti) 表達，抗體(ti) 人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為(wei) 客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yang) 、抗體(ti) 修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體(ti) 定製服務:
已注冊(ce) 商標，主要用於(yu) 抗體(ti) 藥物發現和開發，是我公司針對有特定應用要求和各種模型測試的客戶量身定製的專(zhuan) 業(ye) 服務，主要麵向工業(ye) 客戶。
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